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Results: We found that FEP patients had significantly higher IL-6, IL-10 and TNF-α levels than healthy controls. After risperidone treatment, these three cytokines and additionally IL-4 decreased significantly. No significant difference was found between the post-treatment cytokine levels in FEP patients and in healthy controls, suggesting that these alterations in cytokine profiles are a state marker of FEP. No significant association was found between risperidone-induced changes in cytokines and the clinical response to treatment or the presence of depression. There was a significant inverse association between the risperidone-induced changes in IL-10 and the negative symptoms.
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FEP n = 55 HC n = 57 F or Χ 2 df p Gender 1.90 1 0.168 Male 65.5% 52.6% Female 34.5% 47.4% Age 24.75 (±7.43) 26.61 (±7.53) -1.32 1/110 0.189 Marital status 4.30 1/2 0.117 Single 87.5% 78.8% Marriage 7.5% 21.2% Divorced 7.5% 0% Years of education 15.15 1/1. FEP n = 55 HC n = 57 F or Χ 2 df p Gender 1.90 1 0.168 Male 65.5% 52.6% Female 34.5% 47.4% Age 24.75 (±7.43) 26.61 (±7.53) -1.32 1/110 0.189 Marital status 4.30 1/2 0.117 Single 87.5% 78.8% Marriage 7.5% 21.2% Divorced 7.5% 0% Years of education 15.15 1/1. FEP n = 55 HC n = 57 F or Χ 2 df p Gender 1.90 1 0.168 Male 65.5% 52.6% Female 34.5% 47.4% Age 24.75 (±7.43) 26.61 (±7.53) -1.32 1/110 0.189 Marital status 4.30 1/2 0.117 Single 87.5% 78.8% Marriage 7.5% 21.2% Divorced 7.5% 0% Years of education 15.15 1/1.
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FEP n = 55 HC n = 57 F or Χ 2 df p Gender 1.90 1 0.168 Male 65.5% 52.6% Female 34.5% 47.4% Age 24.75 (±7.43) 26.61 (±7.53) -1.32 1/110 0.189 Marital status 4.30 1/2 0.117 Single 87.5% 78.8% Marriage 7.5% 21.2% Divorced 7.5% 0% Years of education 15.15 1/1. Effect of Risperidone Treatment on Cytokines and Clinical Levels shows the cytokine level measurements at baseline and post-treatment in FEP patients when compared to healthy controls. Also shows the comparison between pre- and post-treatment cytokines and psychopathology data as a time factor and a time x gender interaction, analyzed with RM design ANOVAs. Treatment with risperidone significantly lowered IL-6, IL-4, IL-10, and TNF-α, while there was a trend towards increased IL-17 levels after treatment. There were no significant interactions between time x gender.
Treatment with risperidone reduced the PANSS general, PANSS positive, CDS, CGI, and GAF scores. There was no significant effect of treatment with risperidone on the PANSS negative subscale score. Changes in the levels of cytokines were not correlated with the dosage of risperidone ( p. HC (n = 57) FEP Pre (n = 55) FEP Post (n = 55) Time F-value* df p Time x Gender F-value* p IL-6 0.77 (±0.04) 1.64 (±1.77) 0.90 (±0.81) 9. Advanced system protector 2 1 1000 10568 whith keystone. 81 1/53 0.003 0.11 0.745 IL-4 0.24 (±0.63) 0.43 (±0.78) 0.03 (±0.09) 16.21 1/53. HC (n = 57) FEP Pre (n = 55) FEP Post (n = 55) Time F-value* df p Time x Gender F-value* p IL-6 0.77 (±0.04) 1.64 (±1.77) 0.90 (±0.81) 9.81 1/53 0.003 0.11 0.745 IL-4 0.24 (±0.63) 0.43 (±0.78) 0.03 (±0.09) 16.21 1/53. HC (n = 57) FEP Pre (n = 55) FEP Post (n = 55) Time F-value* df p Time x Gender F-value* p IL-6 0.77 (±0.04) 1.64 (±1.77) 0.90 (±0.81) 9.81 1/53 0.003 0.11 0.745 IL-4 0.24 (±0.63) 0.43 (±0.78) 0.03 (±0.09) 16.21 1/53. HC (n = 57) FEP Pre (n = 55) FEP Post (n = 55) Time F-value* df p Time x Gender F-value* p IL-6 0.77 (±0.04) 1.64 (±1.77) 0.90 (±0.81) 9.81 1/53 0.003 0.11 0.745 IL-4 0.24 (±0.63) 0.43 (±0.78) 0.03 (±0.09) 16.21 1/53.
Results of ANOVAs showed that pre-treatment IL-6 levels in FEP patients were significantly higher than in controls (F = 9.89, df = 1/112, p = 0.002), whereas post-treatment IL-6 values in FEP patients were not significantly different from those in controls (F = 0.41, df = 1/110, p = 0.524). Pre-treatment IL-4 levels of FEP patients were not significantly different from IL-4 levels in controls (F = 2.15, df = 1/110, p = 0.145), whereas the post-treatment IL-4 levels were significantly lower in FEP patients than in controls (F = 6.00, df = 1/110, p = 0.016). The pre-treatment IL-10 levels of FEP patients were significantly higher than those in healthy controls (F = 18.82, df = 1/110, p. Responders Non-responders Time F-value* df p Time x Responder status F-value* df P CDS PRE 6.56 (±5.89) 4.79 (±6.54) 5.91 1/35 0.020 1.66 1/35 0.207 POST 2.13 (±3.30) 3.42 (±5.11) PANSS Total PRE 104.39 (±21.60) 97.10 (±20.64) 163.76 1/35. Responders Non-responders Time F-value* df p Time x Responder status F-value* df P CDS PRE 6.56 (±5.89) 4.79 (±6.54) 5.91 1/35 0.020 1.66 1/35 0.207 POST 2.13 (±3.30) 3.42 (±5.11) PANSS Total PRE 104.39 (±21.60) 97.10 (±20.64) 163.76 1/35. Responders Non-responders Time F-value* df p Time x Responder status F-value* df P CDS PRE 6.56 (±5.89) 4.79 (±6.54) 5.91 1/35 0.020 1.66 1/35 0.207 POST 2.13 (±3.30) 3.42 (±5.11) PANSS Total PRE 104.39 (±21.60) 97.10 (±20.64) 163.76 1/35. Responders Non-responders Time F-value* df p Time x Responder status F-value* df P CDS PRE 6.56 (±5.89) 4.79 (±6.54) 5.91 1/35 0.020 1.66 1/35 0.207 POST 2.13 (±3.30) 3.42 (±5.11) PANSS Total PRE 104.39 (±21.60) 97.10 (±20.64) 163.76 1/35.
Responders Non Responders Time F-value* df p Time x Responder status F-value* df p IL-6 PRE 1.92 (±2.01) 1.49 (±1.95) 6. How to install leaf springs on a trailer. 21 1/35 0.018 0.00 1/35 0.950 POST 1.09 (±1.09) 0.70 (±0.44) IL-4 PRE 0.48 (±0.18) 0.34 (±0.78) 8.73 1/35 0.006 0.17 1/35 0.681 POST 0.05 (±0.14) 0.02 (±0.05) IL-10 PRE 1.13 (±1.13) 0.75 (±0.89) 13.54 1/35. Responders Non Responders Time F-value* df p Time x Responder status F-value* df p IL-6 PRE 1.92 (±2.01) 1.49 (±1.95) 6.21 1/35 0.018 0.00 1/35 0.950 POST 1.09 (±1.09) 0.70 (±0.44) IL-4 PRE 0.48 (±0.18) 0.34 (±0.78) 8.73 1/35 0.006 0.17 1/35 0.681 POST 0.05 (±0.14) 0.02 (±0.05) IL-10 PRE 1.13 (±1.13) 0.75 (±0.89) 13.54 1/35. Responders Non Responders Time F-value* df p Time x Responder status F-value* df p IL-6 PRE 1.92 (±2.01) 1.49 (±1.95) 6.21 1/35 0.018 0.00 1/35 0.950 POST 1.09 (±1.09) 0.70 (±0.44) IL-4 PRE 0.48 (±0.18) 0.34 (±0.78) 8.73 1/35 0.006 0.17 1/35 0.681 POST 0.05 (±0.14) 0.02 (±0.05) IL-10 PRE 1.13 (±1.13) 0.75 (±0.89) 13.54 1/35. Responders Non Responders Time F-value* df p Time x Responder status F-value* df p IL-6 PRE 1.92 (±2.01) 1.49 (±1.95) 6.21 1/35 0.018 0.00 1/35 0.950 POST 1.09 (±1.09) 0.70 (±0.44) IL-4 PRE 0.48 (±0.18) 0.34 (±0.78) 8.73 1/35 0.006 0.17 1/35 0.681 POST 0.05 (±0.14) 0.02 (±0.05) IL-10 PRE 1.13 (±1.13) 0.75 (±0.89) 13.54 1/35. Correlation Between Cytokines Levels and the Presence of Depression shows the results of RM design ANOVAs with time (pre- and post-treatment cytokines data) and time x diagnostic depression groups (patients divided according to the baseline CDS values using a threshold value >5) as within-subject contrasts. We found significant interactions between time x diagnostic groups for IL-4 and TNF-α.